Successful pregnancy after chemotherapy for choriocarcinoma.

Choriocarcinoma is an aggressive malignant disease that originates in the trophoblastic cells of the placenta, characterized by early hematogenous spread to the lungs. It belongs to the far spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumor. It is a hypervascular tumor composed of sheets of malignant cytotrophoblast and syncytiotrophoblast metastasizing hematogenously and producing a dramatic rise in b hCG levels. Rarely it occurs in primary locations other than the placenta. The majority of metastasis affect lungs (80 %), vagina (30 %), ovaries (20 %), liver (10 %), brain(10 %), ureter and bowel (5 %) each [1].